Open AccessA Breakdown in Cooperativity Leads to Cardiac Identity Crisis
Author(s) -
Ana Vujić,
Ahmed I. Mahmoud,
Richard Lee
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.11.056
Subject(s) - biology , cooperativity , identity (music) , identity crisis , genetics , social psychology , psychology , physics , personality , acoustics
Using induced pluripotent stem cells, Ang et al. elucidate how a mutation in the transcription factor GATA4 causes congenital heart disease. They find that, although the recruitment of GATA4 to cardiac super-enhancers is retained, it no longer functions in partnership with another key transcription factor, leading to misexpression of non-cardiomyocyte genes.
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