A Zygotic Checkpoint for Unrepaired Lesions | Zendy

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A Zygotic Checkpoint for Unrepaired Lesions

Author(s) -

Lee Zou

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.11.049

Subject(s) - dna demethylation , reprogramming , biology , zygote , dna repair , genetics , g2 m dna damage checkpoint , dna damage , dna methylation , microbiology and biotechnology , dna , cell cycle checkpoint , cell cycle , embryo , gene , embryogenesis , gene expression

DNA demethylation, a process involving DNA repair, is critical for reprogramming of the paternal genome during the oocyte-to-zygote transition. A new study by Ladstätter and Tachibana-Konwalski shows that a Chk1-mediated zygotic checkpoint monitors the cohesin-dependent repair of DNA lesions arising from DNA demethylation, which prevents zygotes carrying unrepaired lesions from entering mitosis.

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