Retromer Sets a Trap for Endosomal Cargo Sorting | Zendy

Ludger Johannes | Zendy; Christian Wunder | Zendy

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Retromer Sets a Trap for Endosomal Cargo Sorting

Author(s) -

Ludger Johannes,

Christian Wunder

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.11.026

Subject(s) - retromer , endosome , biology , vesicular transport proteins , microbiology and biotechnology , sorting nexin , golgi apparatus , transport protein , sorting , vacuolar protein sorting , computer science , intracellular , endoplasmic reticulum , programming language

Membrane trafficking from endosomes to the trans-Golgi network or the plasma membrane is driven by the retromer complex. Through structural analysis of the cargo-bound complex, Lucas et al. describe a mechanism by which endosomal membrane recruitment and cargo recognition are integrated through cooperative interactions between retromer subunits.

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