The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome | Zendy

Cailyn H. Spurrell | Zendy; Diane E. Dickel | Zendy; Axel Visel | Zendy

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The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome

Author(s) -

Cailyn H. Spurrell,

Diane E. Dickel,

Axel Visel

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.10.054

Subject(s) - enhancer , biology , promoter , chromosome conformation capture , chromatin , transcription factor , genetics , gene , computational biology , interactome , regulatory sequence , regulation of gene expression , genome , gene expression

Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. In this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage- and cell-type-specific dynamics of interactions between regulators and gene promoters.

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