RETRACTED: FMN2 Makes Perinuclear Actin to Protect Nuclei during Conﬁned Migration and Promote Metastasis | Zendy

Colleen T. Skau | Zendy; Robert Fischer | Zendy; Pinar S. Gurel | Zendy; Hawa Racine Thiam | Zendy; Anthony Tubbs | Zendy; Michelle A. Baird | Zendy; Michael W. Davidson | Zendy; Matthieu Piel | Zendy; Gregory M. Alushin | Zendy; André Nussenzweig | Zendy; Patricia S. Steeg | Zendy; Clare M. Waterman | Zendy

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RETRACTED: FMN2 Makes Perinuclear Actin to Protect Nuclei during Conﬁned Migration and Promote Metastasis

Author(s) -

Colleen T. Skau,

Robert Fischer,

Pinar S. Gurel,

Hawa Racine Thiam,

Anthony Tubbs,

Michelle A. Baird,

Michael W. Davidson,

Matthieu Piel,

Gregory M. Alushin,

André Nussenzweig,

Patricia S. Steeg,

Clare M. Waterman

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.10.023

Subject(s) - biology , formins , actin , cell migration , microbiology and biotechnology , extravasation , cytoskeleton , metastasis , cell , actin cytoskeleton , cancer research , immunology , cancer , genetics

Cell migration in confined 3D tissue microenvironments is critical for both normal physiological functions and dissemination of tumor cells. We discovered a cytoskeletal structure that prevents damage to the nucleus during migration in confined microenvironments. The formin-family actin filament nucleator FMN2 associates with and generates a perinuclear actin/focal adhesion (FA) system that is distinct from previously characterized actin/FA structures. This system controls nuclear shape and positioning in cells migrating on 2D surfaces. In confined 3D microenvironments, FMN2 promotes cell survival by limiting nuclear envelope damage and DNA double-strand breaks. We found that FMN2 is upregulated in human melanomas and showed that disruption of FMN2 in mouse melanoma cells inhibits their extravasation and metastasis to the lung. Our results indicate a critical role for FMN2 in generating a perinuclear actin/FA system that protects the nucleus and DNA from damage to promote cell survival during confined migration and thus promote cancer metastasis.

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