Open AccessPIWI Takes a Giant Step
Author(s) -
Yibei Xiao,
Ailong Ke
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.09.043
Subject(s) - piwi interacting rna , biology , argonaute , rasirna , genetics , transposable element , rna , gene silencing , biogenesis , small rna , rna interference , computational biology , gene , genome
piRNA guides the action of PIWI proteins to silence deleterious transposons in animal reproductive tissues. Biogenesis of piRNA-induced silencing complex (piRISC) involves a multi-step process. In this issue, Matsumoto et al. report the first crystal structure of a PIWI-clade protein displaying a guide RNA, ready for action.
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