Coordination of Two Genomes by Mitochondrial Translational Plasticity | Zendy

Heike Rampelt | Zendy; Nikolaus Pfanner | Zendy

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Coordination of Two Genomes by Mitochondrial Translational Plasticity

Author(s) -

Heike Rampelt,

Nikolaus Pfanner

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.09.042

Subject(s) - biology , mitochondrion , mitochondrial ribosome , ribosome , microbiology and biotechnology , mitochondrial carrier , cytosol , respiratory chain , inner mitochondrial membrane , oxidative phosphorylation , biochemistry , gene , rna , bacterial outer membrane , escherichia coli , enzyme

The dual genetic origin of mitochondrial respiratory chain complexes leads to the synthesis of subunits by mitochondrial and cytosolic ribosomes. Now, Richter-Dennerlein et al. report that membrane-integrated assembly factors associate with ribosome nascent chain complexes in human mitochondria to coordinate translational plasticity with the import of subunits from the cytosol.

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