ALKBH1-Mediated tRNA Demethylation Regulates Translation | Zendy

Fange Liu | Zendy; Wesley C. Clark | Zendy; GuanZheng Luo | Zendy; Xiaoyun Wang | Zendy; Ye Fu | Zendy; Jiangbo Wei | Zendy; Xiao Wang | Zendy; Ziyang Hao | Zendy; Qing Dai | Zendy; Guanqun Zheng | Zendy; Honghui Ma | Zendy; Dali Han | Zendy; Molly Evans | Zendy; Arne Klungland | Zendy; Tao Pan | Zendy; Chuan He | Zendy

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ALKBH1-Mediated tRNA Demethylation Regulates Translation

Author(s) -

Fange Liu,

Wesley C. Clark,

GuanZheng Luo,

Xiaoyun Wang,

Ye Fu,

Jiangbo Wei,

Xiao Wang,

Ziyang Hao,

Qing Dai,

Guanqun Zheng,

Honghui Ma,

Dali Han,

Molly Evans,

Arne Klungland,

Tao Pan,

Chuan He

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.09.038

Subject(s) - demethylation , biology , demethylase , transfer rna , translation (biology) , protein biosynthesis , methylation , microbiology and biotechnology , t arm , dna methylation , genetics , gene expression , gene , epigenetics , messenger rna , rna

tRNA is a central component of protein synthesis and the cell signaling network. One salient feature of tRNA is its heavily modified status, which can critically impact its function. Here, we show that mammalian ALKBH1 is a tRNA demethylase. It mediates the demethylation of N 1 -methyladenosine (m 1 A) in tRNAs. The ALKBH1-catalyzed demethylation of the target tRNAs results in attenuated translation initiation and decreased usage of tRNAs in protein synthesis. This process is dynamic and responds to glucose availability to affect translation. Our results uncover reversible methylation of tRNA as a new mechanism of post-transcriptional gene expression regulation.

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