Customizing Functionality and Payload Delivery for Receptor-Engineered T Cells | Zendy

Christopher A. Klebanoff | Zendy; Nicholas P. Restifo | Zendy

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Customizing Functionality and Payload Delivery for Receptor-Engineered T Cells

Author(s) -

Christopher A. Klebanoff,

Nicholas P. Restifo

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.09.033

Subject(s) - biology , payload (computing) , adoptive immunotherapy , chimeric antigen receptor , cancer immunotherapy , immunotherapy , cancer therapy , computational biology , adoptive cell transfer , receptor , cancer research , cancer , bioinformatics , immunology , t cell , immune system , computer science , genetics , network packet , computer network

Adoptive immunotherapy using receptor engineering to achieve specific tumor targeting by T cells holds much promise for advancing cancer therapy. Here, two studies by Boice et al. and Roybal et al. provide distinct and potentially complimentary approaches to improve the efficacy and curb potential toxicities of this approach.

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