Empowering Older Antibiotics | Zendy

Gerard D. Wright | Zendy

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Empowering Older Antibiotics

Author(s) -

Gerard D. Wright

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.09.032

Subject(s) - periplasmic space , biology , antibiotics , ceftazidime , cephalosporin , microbiology and biotechnology , cephalosporin antibiotic , penicillin , ceftazidime/avibactam , beta lactamase inhibitors , penicillin binding proteins , avibactam , bacteria , biochemistry , escherichia coli , genetics , pseudomonas aeruginosa , gene

Avycaz combines an older cephalosporin antibiotic, ceftazidime, and the β-lactamase inhibitor avibactam. Ceftazidime targets penicillin-binding proteins (PBPs) in the bacterial periplasm that are required for cell wall synthesis. Avibactam blocks β-lactamases (β-L) in the periplasm, which would otherwise inactivate the antibiotics resulting in drug resistance.

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