Open Accessp62 in Cancer: Signaling Adaptor Beyond Autophagy
Author(s) -
Jorge Moscat,
Michael Karin,
Marı́a T. Diaz-Meco
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.09.030
Subject(s) - biology , signal transducing adaptor protein , autophagy , microbiology and biotechnology , cancer , signal transduction , genetics , apoptosis
Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.
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