Probing the Diversity of T Cell Dysfunction in Cancer | Zendy

Ryan Sowell | Zendy; Susan M. Kaech | Zendy

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Probing the Diversity of T Cell Dysfunction in Cancer

Author(s) -

Ryan Sowell,

Susan M. Kaech

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.08.058

Subject(s) - biology , t cell receptor , t cell , pancreatic cancer , cancer , cancer research , immunity , homeostasis , dysfunctional family , microbiology and biotechnology , receptor , immunology , immune system , genetics , psychology , psychotherapist

T cell dysfunction in cancer comes in many forms, with two new varieties reported in this issue. Daley et al. find that T cells expressing γδ T cell receptors (TCR) promote pancreatic tumor growth by inhibiting activation of T cells with conventional TCRs. Singer et al. characterize dysfunctional tumor infiltrating lymphocytes to reveal a role for zinc homeostasis in anti-tumor immunity.

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