Open AccessTag Team Ubiquitin Ligases
Author(s) -
Gary Kleiger,
Raymond J. Deshaies
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.08.014
Subject(s) - cullin , ubiquitin , biology , ubiquitin ligase , ubiquitin protein ligases , enzyme , biochemistry , microbiology and biotechnology , dna ligase , cop9 signalosome , protease , gene , peptide hydrolases
Cullin-RING (CRL) and RING1-IBR-RING2 (RBR) are two distinct types of ubiquitin ligases. In this issue, Scott et al. show that CRLs activate the RBR enzyme ARIH1 to initiate ubiquitin chains on CRL substrates, thereby marking an unexpected and important advance in our understanding of both enzymes.
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