Open AccessThe Whole (Cell) Is Less Than the Sum of Its Parts
Author(s) -
Jonathan G. Van Vranken,
Jared Rutter
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.08.011
Subject(s) - biology , metabolome , organelle , compartmentalization (fire protection) , computational biology , metabolomics , metabolite , cell , microbiology and biotechnology , bioinformatics , biochemistry , enzyme
Despite advances in metabolite profiling, a full picture of the metabolic landscape of the cell has been limited by sub-cellular compartmentalization, which segregates distinct nutrient pools into membrane-bound organelles. Now, Chen et al. describe methods for overcoming this hurdle and provide a new quantitative picture of the mitochondrial metabolome.
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