Open AccessBile Acid Analog Intercepts Liver Fibrosis
Author(s) -
C. Daniel De Magalhaes Filho,
Michael Downes,
Ronald M. Evans
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.08.001
Subject(s) - ursodeoxycholic acid , bile acid , biology , medicine , gastroenterology , liver fibrosis , liver disease , primary biliary cirrhosis , fibrosis , biochemistry , immunology
Ocaliva, a synthetic bile acid analog with high affinity for the nuclear bile acid receptor FXR, is effective in treating primary biliary cholangitis, an autoimmune liver disease. It works in patients who fail to respond to or cannot tolerate conventional treatment with the natural bile acid ursodeoxycholic acid (UDCA).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom