Epigenetic Mechanisms of Longevity and Aging | Zendy

Payel Sen | Zendy; Parisha P. Shah | Zendy; Raffaella Nativio | Zendy; Shelley L. Berger | Zendy

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Epigenetic Mechanisms of Longevity and Aging

Author(s) -

Payel Sen,

Parisha P. Shah,

Raffaella Nativio,

Shelley L. Berger

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.07.050

Subject(s) - biology , longevity , epigenetics , epigenesis , evolutionary biology , genetics , computational biology , dna methylation , gene , gene expression

Aging is an inevitable outcome of life, characterized by progressive decline in tissue and organ function and increased risk of mortality. Accumulating evidence links aging to genetic and epigenetic alterations. Given the reversible nature of epigenetic mechanisms, these pathways provide promising avenues for therapeutics against age-related decline and disease. In this review, we provide a comprehensive overview of epigenetic studies from invertebrate organisms, vertebrate models, tissues, and in vitro systems. We establish links between common operative aging pathways and hallmark chromatin signatures that can be used to identify "druggable" targets to counter human aging and age-related disease.

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