Memory of Inflammation in Regulatory T Cells | Zendy

Joris van der Veeken | Zendy; Álvaro González | Zendy; Hyunwoo Cho | Zendy; Aaron Arvey | Zendy; Saskia Hemmers | Zendy; Christina Leslie | Zendy; Alexander Y. Rudensky | Zendy

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Memory of Inflammation in Regulatory T Cells

Author(s) -

Joris van der Veeken,

Álvaro González,

Hyunwoo Cho,

Aaron Arvey,

Saskia Hemmers,

Christina Leslie,

Alexander Y. Rudensky

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.07.006

Subject(s) - biology , inflammation , immunology , microbiology and biotechnology , suppressor , population , function (biology) , epigenomics , immunosuppression , regulatory t cell , t cell , il 2 receptor , immune system , gene , genetics , gene expression , dna methylation , demography , sociology

Eukaryotic cells can "remember" transient encounters with a wide range of stimuli, inducing lasting states of altered responsiveness. Regulatory T (Treg) cells are a specialized lineage of suppressive CD4 T cells that act as critical negative regulators of inflammation in various biological contexts. Treg cells exposed to inflammatory conditions acquire strongly enhanced suppressive function. Using inducible genetic tracing, we analyzed the long-term stability of activation-induced transcriptional, epigenomic, and functional changes in Treg cells. We found that the inflammation-experienced Treg cell population reversed many activation-induced changes and lost its enhanced suppressive function over time. The "memory-less" potentiation of Treg suppressor function may help avoid a state of generalized immunosuppression that could otherwise result from repeated activation.

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