Open AccessMitochondrial Networking in T Cell Memory
Author(s) -
Marc Liesa,
Orian Shirihai
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.06.035
Subject(s) - biology , mitochondrion , microbiology and biotechnology , bioenergetics , context (archaeology) , t cell , mitochondrial fusion , biochemistry , mitochondrial dna , immunology , paleontology , immune system , gene
T-lymphocytes show large changes in ATP demand and nutrient utilization, imposed by their different roles as T memory and T effector cells. Therefore, T cell remodeling represents a bioenergetic challenge to mitochondria. New work from Buck et al. links changes in mitochondrial shape to T cell fate choice.
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