Open AccessOpening a Chromatin Gate to Metastasis
Author(s) -
John D. Minna,
Jane E. Johnson
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.06.031
Subject(s) - metastasis , biology , lung cancer , cancer , cancer research , oncology , medicine , bioinformatics
What changes need to occur in a primary tumor to make it metastatic? Denny et al. address this question for small cell lung cancer (SCLC), finding that changes in genomic accessibility mediated by a single transcription factor, NFIB, comprise at least one mechanism influencing metastasis.
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