Evidence of G.O.D.’s Miracle: Unearthing a RAG Transposon | Zendy

Martin F. Flajnik | Zendy

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Evidence of G.O.D.’s Miracle: Unearthing a RAG Transposon

Author(s) -

Martin F. Flajnik

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.06.021

Subject(s) - biology , chordate , transposable element , rag2 , recombination activating gene , transposase , gene , genetics , immunoglobulin superfamily , evolutionary biology , vertebrate , genome , recombination

Diversity of antibodies and T cell receptors is generated by gene rearrangement dependent on RAG1 and RAG2, enzymes predicted to have been derived from a transposable element (TE) that invaded an immunoglobulin superfamily gene early in the evolution of jawed vertebrates. Now, Huang et al. report the discovery of ProtoRAG in the lower chordate Amphioxus, the long-anticipated TE related to the RAG transposon.

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