Open AccessColonic Crypts: Safe Haven from Microbial Products
Author(s) -
Hugo J.G. Snippert
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.06.003
Subject(s) - biology , crypt , stem cell , metabolite , safe haven , microbiology and biotechnology , biochemistry , international economics , economics , endocrinology
The notion that the colon's deep crypt pockets provide a protected location that shields stem cells from potentially toxic substances is widely accepted. In this issue of Cell, Kaiko et al. reveal how a metabolite abundantly produced by the gut microbiota can inhibit stem cell proliferation but is blocked from doing so by crypt architecture.
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