Open AccessA BH3 Mimetic for Killing Cancer Cells
Author(s) -
Douglas R. Green
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.05.080
Subject(s) - venetoclax , biology , chronic lymphocytic leukemia , apoptosis , cancer cell , cancer research , cancer , antagonism , leukemia , programmed cell death , immunology , genetics , receptor
Venetoclax is a BH3 mimetic approved for treating chronic lymphocytic leukemia. Cancer cells are resistant to apoptosis but "primed for death" by elevated BCL-2, which binds to pro-apoptotic proteins and holds them in check. Venetoclax releases this antagonism and is the first approved drug to target a protein-protein interaction.
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