Open AccessA Pro-metastatic tRNA Pathway
Author(s) -
Canan Kuscu,
Anindya Dutta
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.05.066
Subject(s) - biology , transfer rna , translation (biology) , protein biosynthesis , downregulation and upregulation , translational efficiency , genetics , gene , computational biology , cancer research , microbiology and biotechnology , messenger rna , rna
RNAs are best known as basic modules for global regulation of protein synthesis. Goodarzi et al. now show that two tRNAs upregulated in metastatic breast cancer cells enhance stability and translation of transcripts enriched with these codons, leading to specific increase in production of pro-metastatic proteins.
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