Open AccessDangerous Entrapment for NRF2
Author(s) -
Vera Gorbunova,
Sarallah Rezazadeh,
Andrei Seluanov
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.05.061
Subject(s) - progeria , lamin , lmna , biology , premature aging , genome instability , oxidative stress , genetics , mutation , microbiology and biotechnology , cancer research , dna damage , gene , biochemistry , dna
Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.
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