Open AccessA TOGgle for Tension at Kinetochores
Author(s) -
Dhanya K. Cheerambathur,
Bram Prevo,
Arshad Desai
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.05.060
Subject(s) - biology , kinetochore , tension (geology) , microbiology and biotechnology , genetics , chromosome , classical mechanics , gene , physics , moment (physics)
Differential stability of kinetochore-microtubule attachments at low versus high tension is critical for accurate chromosome segregation. Miller et al. find that a TOG domain microtubule-binding protein imparts intrinsic tension selectivity to kinetochore-microtubule attachments.
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