p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer | Zendy

Darjus F. Tschaharganeh | Zendy; Wen Xue | Zendy; Diego F. Calvisi | Zendy; Matthias Evert | Zendy; Tatyana V. Michurina | Zendy; Lukas E. Dow | Zendy; Ana Banito | Zendy; S.-F. Katz | Zendy; Edward R. Kastenhuber | Zendy; Susann Weissmueller | Zendy; ChunHao Huang | Zendy; André Lechel | Zendy; Jesper B. Andersen | Zendy; David Capper | Zendy; Lars Zender | Zendy; Thomas Longerich | Zendy; Grigori Enikolopov | Zendy; Scott W. Lowe | Zendy

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p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer

Author(s) -

Darjus F. Tschaharganeh,

Wen Xue,

Diego F. Calvisi,

Matthias Evert,

Tatyana V. Michurina,

Lukas E. Dow,

Ana Banito,

S.-F. Katz,

Edward R. Kastenhuber,

Susann Weissmueller,

ChunHao Huang,

André Lechel,

Jesper B. Andersen,

David Capper,

Lars Zender,

Thomas Longerich,

Grigori Enikolopov,

Scott W. Lowe

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.05.058

Subject(s) - nestin , biology , mcherry , carcinogenesis , microbiology and biotechnology , liver cancer , neural stem cell , cancer research , green fluorescent protein , cancer , hepatocellular carcinoma , stem cell , genetics , gene

(Cell 158, 579–592; July 31, 2014) In the above article, which shows that transcriptional repression of Nestin by p53 restricts cellular plasticity and tumorigenesis in liver cancer, there is a duplicated micrograph panel in Figure 7E. This figure shows the characterization of cholangiocarcinomas arising after delivery of two vector constructs in murine livers (GFP-YAP;shp53 and mCherry-NICD). Panel E documents the expression of GFP (indicating YAP;shp53) and mCherry (indicating NICD), as well as positivity of HNF1b and Nestin staining. Owing to a labeling error, two different photographs of the GFP slide were inadvertently used in the panel, with one incorrectly being labeled asmCherry. A revised version of Figure 7E with the correct micrograph showing mCherry expression is now provided below and supports the original conclusions that expression of GFP andmCherry in the tissue mostly overlaps. We apologize for any confusion that this error may have caused.

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