The Molecular and Cellular Choreography of Appendage Regeneration | Zendy

Elly M. Tanaka | Zendy

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The Molecular and Cellular Choreography of Appendage Regeneration

Author(s) -

Elly M. Tanaka

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.05.038

Subject(s) - regeneration (biology) , biology , context (archaeology) , vertebrate , neuroscience , microbiology and biotechnology , genetics , paleontology , gene

Recent advances in limb regeneration are revealing the molecular events that integrate growth control, cell fate programming, and positional information to yield the exquisite replacement of the amputated limb. Parallel progress in several invertebrate and vertebrate models has provided a broader context for understanding the mechanisms and the evolution of regeneration. Together, these discoveries provide a foundation for describing the principles underlying regeneration of complex, multi-tissue structures. As such these findings should provide a wealth of ideas for engineers seeking to reconstitute regeneration from constituent parts or to elicit full regeneration from partial regeneration events.

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