Open AccessMitochondria: Masters of Epigenetics
Author(s) -
Marc Tatar,
John M. Sedivy
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.05.021
Subject(s) - biology , epigenetics , mitochondrion , phenotype , epigenesis , offspring , genetics , physiology , dna methylation , pregnancy , gene , gene expression
Accumulating evidence argues that aging exerts a profound influence on epigenetics, and vice versa. A pair of studies by Merkwirth et al. and Tian et al. now provide insights on how mitochondrial stress experienced by C. elegans larvae propagates a specific and persistent epigenetic response that protects adult cells and extends lifespan.
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