Open AccessSwollen Nuclei Signal from the Grave
Author(s) -
Wakam Chang,
Gregg G. Gundersen
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.05.015
Subject(s) - eicosanoid , biology , microbiology and biotechnology , signal transduction , cell , eicosanoid metabolism , chromosomal translocation , enzyme , biochemistry , arachidonic acid , gene
Eicosanoid signaling plays key pro-inflammatory roles during tissue damage. Now, Enyedi et al. show that swelling of nuclei in cell corpses activates eicosanoid signaling to recruit leukocytes to sites of tissue damage. The enhanced membrane tension in swollen nuclei directly promotes calcium-dependent translocation and activation of enzymes involved in eicosanoid biosynthesis.
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