Open AccessTension-Time Integrals and Genetic Cardiomyopathy: The Force Is with You
Author(s) -
Gerald W. Dorn
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.04.036
Subject(s) - biology , tension (geology) , cardiomyopathy , medicine , classical mechanics , heart failure , physics , moment (physics)
Hundreds of different mutations in genes encoding a few dozen sarcomeric proteins cause two reciprocal human disease phenotypes, hypertrophic or dilated cardiomyopathy. How molecular dysfunction evokes different patterns of cardiac remodeling is unclear. Davis et al. describe a biophysical metric of cardiomyocyte function, the force-time integral, which predicts disease phenotype.
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