Types of Ubiquitin Ligases | Zendy

Francesca Morreale | Zendy; Helen Walden | Zendy

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Types of Ubiquitin Ligases

Author(s) -

Francesca Morreale,

Helen Walden

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.03.003

Subject(s) - biology , ubiquitin , ubiquitin protein ligases , computational biology , microbiology and biotechnology , genetics , ubiquitin ligase , evolutionary biology , bioinformatics , gene

Ubiquitination is a post-translational modification of proteins involved in a variety of cellular processes. Ubiquitination requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases). This SnapShot highlights the main types of E3 ubiquitin ligases, which can be classified in three families depending on the presence of characteristic domains and on the mechanism of ubiquitin transfer to the substrate protein.

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