Mice Lacking TLR11 Exhibit Variable Salmonella typhi Susceptibility | Zendy

Ramkumar Mathur | Zendy; Wangyong Zeng | Zendy; Matthew S. Hayden | Zendy; Sankar Ghosh | Zendy

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Mice Lacking TLR11 Exhibit Variable Salmonella typhi Susceptibility

Author(s) -

Ramkumar Mathur,

Wangyong Zeng,

Matthew S. Hayden,

Sankar Ghosh

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.02.020

Subject(s) - biology , scopus , salmonella , flagellin , humanities , microbiology and biotechnology , genetics , medline , philosophy , bacteria , biochemistry

We have reported that TLR11 contributes to the murine response to flagellin and resistance to infection with Salmonella spp., including those responsible for typhoid fever in humans (Mathur et al., 2012). Here, we respond to the Correspondence in this issue of Cell by Song et al. (2016), which claims that mice lacking TLR11 are not more susceptible to infection with Salmonella species and that TLR11 does not recognize Salmonella flagellin.

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