Expanding the Ubiquitin Code | Zendy

Krishnaraj Rajalingam | Zendy; Ivan Đikić | Zendy

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Expanding the Ubiquitin Code

Author(s) -

Krishnaraj Rajalingam,

Ivan Đikić

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.02.019

Subject(s) - biology , ubiquitin , computational biology , genetics , microbiology and biotechnology , gene

The Ubiquitin (Ub) system coordinates vital cellular processes by controlling lifetime, signaling, and binding properties of proteins. Ub serves as a multivalent protein tag that is further diversified by post-translational modifications. Specialized Ub receptors then convert the encoded signals into cellular responses. This SnapShot highlights the importance of the rapidly expanding Ub code in biology as well as novel pharmacological approaches to target the Ub system in multiple diseases. To view this SnapShot, open or download the PDF.

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