Open AccessGround Control to Major Tom: The Cell Body Signals Axon Degeneration
Author(s) -
Wendy Knowlton,
Yishi Jin
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.02.013
Subject(s) - axon , biology , neuroscience , degeneration (medical) , nervous system , pathology , medicine
Axon degeneration in response to trophic deprivation was thought to be locally restricted to the axon. However, increasing evidence points to a requirement for the cell body in the degenerative program. Now, Simon et al. identify the pro-apoptotic protein Puma as a key factor in this cell body-derived signal.
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