Open AccessPluripotency without Proliferation
Author(s) -
Xiaodong Shu,
Duanqing Pei
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.01.050
Subject(s) - biology , embryonic stem cell , rex1 , microbiology and biotechnology , induced pluripotent stem cell , genetics , gene
Mouse embryonic stem cells (mESCs) are capable of unlimited proliferation without losing pluripotency. Scognamiglio et al. now reveal that Myc depletion shifts mESCs into a dormant state reminiscent of embryonic diapause in which pluripotency remains fully preserved, thus decoupling pluripotency from proliferative programs.
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