Open AccessA Mechanism for Somatic Brain Mosaicism
Author(s) -
Irving L. Weissman,
Fred H. Gage
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.01.048
Subject(s) - biology , somatic cell , mechanism (biology) , genetics , evolutionary biology , neuroscience , computational biology , gene , philosophy , epistemology
Double-strand break repair is required for neural development, and brain cells contain somatic genomic variations. Now, Wei et al. demonstrate that neural stem and progenitor cells undergo very frequent DNA breaks in a very restricted set of genes involved in neural cell adhesion and synapse function.
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