Open AccessNot All Created Equal: Lineage Hard-Wiring in the Production of Blood
Author(s) -
François Mercier,
David T. Scadden
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.12.013
Subject(s) - biology , lineage (genetic) , production (economics) , evolutionary biology , genetics , gene , economics , macroeconomics
The multiple cell types comprising blood have been thought to emerge from progenitors with progressively narrower lineage options. New data suggest that lineage fate may be determined earlier than thought and that myeloid progenitor populations are aggregates of individual lineage-restricted cells.
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