Open AccessCell-to-Cell Transcript Variability: Seeing Signal in the Noise
Author(s) -
Kevin A. Janes
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.12.010
Subject(s) - biology , transcription (linguistics) , chromatin , genetics , gene expression , gene , rna polymerase ii , rna , cell , nucleus , microbiology and biotechnology , promoter , philosophy , linguistics
How stochastic is gene expression in mammalian cells? Not very, according to Battich et al., who report that single-cell variability in cytoplasmic mRNAs is remarkably predictable given measurements of a cell's phenotypic state and microenvironment. The noise from transcriptional bursts is buffered by a hallmark of eukaryotes-the nucleus.
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