Open AccessAstrocytes Underlie Neuroinflammatory Memory Impairment
Author(s) -
Lindsay A. Osso,
Jonah R. Chan
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.12.001
Subject(s) - neuroinflammation , neuroscience , multiple sclerosis , neurodegeneration , biology , immune system , inflammation , immunology , disease , medicine , pathology
Neuroinflammation is being increasingly recognized as a potential mediator of cognitive impairments in various neurological conditions. Habbas et al. demonstrate that the pro-inflammatory cytokine tumor necrosis factor alpha signals through astrocytes to alter synaptic transmission and impair cognition in a mouse model of multiple sclerosis.
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