Open AccessA Metabolic Switch for Th17 Pathogenicity
Author(s) -
Fred P. Davis,
Yuka Kanno,
John J. O’Shea
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.11.033
Subject(s) - biology , gene , autoimmunity , inflammation , gene expression , interleukin 23 , pathogenicity , microbiology and biotechnology , genetics , interleukin 17 , immunology , immune system
T helper 17 (Th17) cells are critical for host defense but can also drive autoimmunity. This divergent behavior is explored by Gaublomme et al. and Wang et al., who identify inflammation-associated genes by measuring gene expression in nearly 1,000 individual Th17 cells and show that CD5L affects the expression of pro-inflammatory genes by altering lipid synthesis.
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