SnapShot: Hypoxia-Inducible Factors | Zendy

Kyoung Eun Lee | Zendy; M. Celeste Simon | Zendy

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SnapShot: Hypoxia-Inducible Factors

Author(s) -

Kyoung Eun Lee,

M. Celeste Simon

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.11.011

Subject(s) - biology , autophagy , hypoxia (environmental) , cellular adaptation , microbiology and biotechnology , snapshot (computer storage) , intracellular , homeostasis , hypoxia inducible factors , mitochondrion , pi3k/akt/mtor pathway , apoptosis , biochemistry , gene , signal transduction , oxygen , chemistry , organic chemistry , computer science , operating system

Molecular oxygen (O2) is a key substrate for mitochondrial ATP production and numerous intracellular biochemical reactions. The maintenance of O2 homeostasis is therefore essential for the survival of most species. During O2 deprivation, mammalian cells rely on multiple adaptations mediated by the hypoxia-inducible factors (HIFs), mTOR, autophagy, and the ER stress response. This SnapShot will summarize recent reports expanding our current understanding of HIF-dependent adaptations to low O2 levels.

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