Open AccessPotent Antibody Protection against an Emerging Alphavirus Threat
Author(s) -
Margaret Kielian,
Erica Ollmann Saphire
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.11.006
Subject(s) - biology , alphavirus , virology , alphavirus infection , antibody , immunology , virus
Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization.
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