A Common Mechanism that Underpins Antibody Diversification | Zendy

Cornelis Murre | Zendy

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A Common Mechanism that Underpins Antibody Diversification

Author(s) -

Cornelis Murre

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.10.075

Subject(s) - somatic hypermutation , biology , immunoglobulin class switching , genetics , v(d)j recombination , gene rearrangement , gene conversion , antibody repertoire , cytidine deaminase , recombination , point mutation , antibody , gene , b cell , microbiology and biotechnology , mutation

Targeting of AID to antibody variable (V) regions results in somatic hypermutation, whereas its recruitment to switch (S) regions leads to class-switch recombination. Yeap et al. find that the mechanism by which variable and switch regions recruit AID essentially is the same but that the two regions differ in the density of double-stranded DNA breaks that are generated. These lead to either point mutations in V exons in somatic hypermutation or deletion of intervening DNA sequences during class switch recombination.

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