Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish | Zendy

Kathrin Reichwald | Zendy; A. Petzold | Zendy; Philipp Koch | Zendy; Bryan Downie | Zendy; Nils Hartmann | Zendy; Stefan Pietsch | Zendy; Mario Baumgart | Zendy; Domitille Chalopin | Zendy; Marius Felder | Zendy; Martin Bens | Zendy; Arne Sahm | Zendy; Karol Szafranski | Zendy; Stefan Taudien | Zendy; Marco Groth | Zendy; Ivan Arisi | Zendy; Anja Weise | Zendy; Samarth Bhatt | Zendy; Virag Sharma | Zendy; Johann M. Kraus | Zendy; Florian Schmid | Zendy; Stefan Priebe | Zendy; Thomas Liehr | Zendy; Matthias Görlach | Zendy; Manuel E. Than | Zendy; Michael Hiller | Zendy; Hans A. Kestler | Zendy; JeanNicolas Volff | Zendy; Manfred Schartl | Zendy; Alessandro Cellerino | Zendy; Christoph Englert | Zendy; Matthias Platzer | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish

Author(s) -

Kathrin Reichwald,

A. Petzold,

Philipp Koch,

Bryan Downie,

Nils Hartmann,

Stefan Pietsch,

Mario Baumgart,

Domitille Chalopin,

Marius Felder,

Martin Bens,

Arne Sahm,

Karol Szafranski,

Stefan Taudien,

Marco Groth,

Ivan Arisi,

Anja Weise,

Samarth Bhatt,

Virag Sharma,

Johann M. Kraus,

Florian Schmid,

Stefan Priebe,

Thomas Liehr,

Matthias Görlach,

Manuel E. Than,

Michael Hiller,

Hans A. Kestler,

JeanNicolas Volff,

Manfred Schartl,

Alessandro Cellerino,

Christoph Englert,

Matthias Platzer

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.10.071

Subject(s) - biology , fish <actinopterygii> , evolutionary biology , genome , chromosome , genetics , gene , fishery

The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic development (diapause) make it an attractive model organism in biomedical research. Here, we report a draft sequence of its genome that allowed us to uncover an intra-species Y chromosome polymorphism representing-in real time-different stages of sex chromosome formation that display features of early mammalian XY evolution "in action." Our data suggest that gdf6Y, encoding a TGF-β family growth factor, is the master sex-determining gene in N. furzeri. Moreover, we observed genomic clustering of aging-related genes, identified genes under positive selection, and revealed significant similarities of gene expression profiles between diapause and aging, particularly for genes controlling cell cycle and translation. The annotated genome sequence is provided as an online resource (http://www.nothobranchius.info/NFINgb).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research