Establishment and Dysfunction of the Blood-Brain Barrier | Zendy

Zhen Zhao | Zendy; Amy R. Nelson | Zendy; Christer Betsholtz | Zendy; Berislav V. Zloković | Zendy

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Establishment and Dysfunction of the Blood-Brain Barrier

Author(s) -

Zhen Zhao,

Amy R. Nelson,

Christer Betsholtz,

Berislav V. Zloković

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.10.067

Subject(s) - biology , blood–brain barrier , neuroscience , pathogenesis , neurovascular bundle , signal transduction , disease , cell type , cell , microbiology and biotechnology , central nervous system , immunology , genetics , pathology , anatomy , medicine

Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases, including Alzheimer's disease.

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