Cardiomyocyte Cell-Cycle Activity during Preadolescence | Zendy

Mark H. Soonpaa | Zendy; David C. Zebrowski | Zendy; Colin Platt | Zendy; Anthony Rosenzweig | Zendy; Felix B. Engel | Zendy; Loren J. Field | Zendy

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Cardiomyocyte Cell-Cycle Activity during Preadolescence

Author(s) -

Mark H. Soonpaa,

David C. Zebrowski,

Colin Platt,

Anthony Rosenzweig,

Felix B. Engel,

Loren J. Field

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.10.037

Subject(s) - preadolescence , biology , cell cycle , microbiology and biotechnology , dna replication , andrology , medicine , cell , dna , genetics

Earlier studies (Soonpaa et al., 1996) revealed a rapid drop-off of ventricular cardiomyocyte cell-cycle activity at birth in mice, followed by a burst of DNA synthesis during the first week of postnatal life which contributed to the formation of multi-nucleated cardiomyocytes by postnatal day 10 (PN10). It has recently been suggested that a second burst of cardiomyocyte cell-cycle activity occurs during preadolescence, between PN14 and PN18, resulting in a 40% increase in cardiomyocyte number (Naqvi et al., 2014).

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