Open AccessTreatment for Hypoactive Sexual Desire
Author(s) -
James G. Pfaus
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.10.015
Subject(s) - biology , autoreceptor , postsynaptic potential , serotonin , dopamine , monoamine neurotransmitter , neuroscience , brainstem , 5 ht receptor , endocrinology , receptor , medicine , sexual desire , biochemistry , gender studies , sociology , human sexuality
Flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-HT1A autoreceptors and block postsynaptic action of serotonin at 5-HT2A receptors. This gradually disinhibits the turnover of other monoamines like dopamine and noradrenaline that are critical for sexual desire
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