Open Access“A Sledgehammer Breaks Glass but Forges Steel”: Bacteria Adhesion Shapes Gut Immunity
Author(s) -
Virginia A. Pedicord,
Daniel Mucida
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.09.040
Subject(s) - biology , adhesion , bacteria , immune system , immunity , microbiology and biotechnology , gut bacteria , immunology , genetics , materials science , composite material
Gut bacteria are known to affect immune cell development, but most intestinal lymphocytes have no direct contact with luminal bacteria. Two studies by Atarashi et al. and Sano et al. shed light on how bacterial adhesion can cue intestinal epithelial cells to direct differentiation of gut T cells.
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