Open AccessA Sympathetic View on Fat by Leptin
Author(s) -
Luis Varela,
Tamas L. Horvath
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.09.016
Subject(s) - leptin , biology , adipose tissue , medicine , endocrinology , sympathetic nervous system , obesity , hormone , white adipose tissue , sympathetic activity , blood pressure , heart rate
Zeng et al. reveal that the lipolytic effect of the hormone leptin is mediated by sympathetic nerve fibers that directly "envelope" white adipocytes. Local activation of the sympathetic input to the fat opens new venues to circumvent central leptin resistance in obesity.
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