Open AccessSnapShot: CRISPR-RNA-Guided Adaptive Immune Systems
Author(s) -
Joshua Carter,
Blake Wiedenheft
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.09.011
Subject(s) - biology , crispr , immune system , snapshot (computer storage) , archaea , computational biology , acquired immune system , biogenesis , gene , genetics , computer science , operating system
Bacteria and archaea have evolved sophisticated adaptive immune systems that reply on CRISPR loci and a diverse cassette of Cas genes that are classified into three main types and at least eleven subtypes. All CRISPR-Cas immune systems operate through three main stages: acquisition, biogenesis, and interference. This SnapShot summarizes our current knowledge of these fascinating immune systems.
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